Review

rabbit tissue inhibitor (Biorbyt)

Biorbyt is a verified supplier

About

News

Press Release

Team

Advisors

Partners

Contact

Bioz Stars

Bioz vStars

Buy from Supplier

Structured Review

Biorbyt rabbit tissue inhibitor
Rabbit Tissue Inhibitor, supplied by Biorbyt, used in various techniques. Bioz Stars score: 93/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rabbit+tissue+inhibitor/TIMP1+antibody/pm39471769-71-12-19
Average 93 stars, based on 12 article reviews

rabbit tissue inhibitor - by Bioz Stars, 2026-09

93/100 stars

Images

other:

Article Title: How malocclusion interferes with tissue inhibitor of metalloproteinase-1 expression and morphology of the articular cartilage of the mandible in female rats.
Article Snippet: Objective: The purpose of this study was to investigate morphological alterations and tissue inhibitor of metalloproteinase-1 expression in the articular cartilage of the mandible under conditions of experimentally induced malocclusion.. Design: Twenty-four 8-week-old female Wistar rats were used and divided into control and experimental groups with two different treatment periods (2 and 4 weeks).. Sagittal malocclusions were orthodontically created, causing mesial movement of the first molars and distalization of the third molars unilaterally and on opposite sides of the arches.

Image Search Results

MMPs and TIMPs families screened in our cohort.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: MMPs and TIMPs families screened in our cohort.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques:

Clinical features of high myopia probands carry the TIMP4 LoF variants.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Clinical features of high myopia probands carry the TIMP4 LoF variants.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques:

Variants and clinical information of individuals with high myopia in our cohort. Two potentially pathogenic variants in the TIMP4 were revealed in this study. ( A ) c.528C>A was detected in 6 families, and c.234_235insAA was detected in one (indicated by white arrow in red box). The sequence of healthy controls and the corresponding sequences harboring the variants are shown. ( B ) Frequency of the TIMP4 LoF variants in the HM population, non-HM population, and gnomAD database. The TIMP4 LoF variants were enriched in the HM cohort. ( C ) Fundus photographs of P3 showed a large and pale optic disc and tigroid fundus of both eyes. The visual evoked potential (VEP) of P5 showed severe latency of 60 and 15 min-arc in OD, severe latency of 60 min-arc, and moderate latency of 15 min-arc in OS. ( D ) Predicted the TIMP4 structure and peptide chain structure of the corresponding variant. The position of c.528C>A is vital to disulfide bond formation, and c.234_235insAA results in the loss of the main structure, including the NTR domain, which is likely to cause NMD.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Variants and clinical information of individuals with high myopia in our cohort. Two potentially pathogenic variants in the TIMP4 were revealed in this study. ( A ) c.528C>A was detected in 6 families, and c.234_235insAA was detected in one (indicated by white arrow in red box). The sequence of healthy controls and the corresponding sequences harboring the variants are shown. ( B ) Frequency of the TIMP4 LoF variants in the HM population, non-HM population, and gnomAD database. The TIMP4 LoF variants were enriched in the HM cohort. ( C ) Fundus photographs of P3 showed a large and pale optic disc and tigroid fundus of both eyes. The visual evoked potential (VEP) of P5 showed severe latency of 60 and 15 min-arc in OD, severe latency of 60 min-arc, and moderate latency of 15 min-arc in OS. ( D ) Predicted the TIMP4 structure and peptide chain structure of the corresponding variant. The position of c.528C>A is vital to disulfide bond formation, and c.234_235insAA results in the loss of the main structure, including the NTR domain, which is likely to cause NMD.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques: Sequencing, Variant Assay

Schematic diagram of the methodology. ( A ) Western blot results of TIMP-4 of wild-type and Timp4 defect rats, the protein expression level decrease in a Timp4 -dose dependent manner. ( B ) The measurement of ocular parameters in SD-OCT and the definition of CT, ACD, LT, VCD, and RT by SD-OCT in this study, AL = CT + ACD + LT + VCD + RT. ( C ) The schematic figure of form deprivation; the definition of ocular change. The diffuser was removed after 72 h. ( D ) Measurement of sclera collagen diameter by electron microscopy. The magnification of left image is 1.5 k and the right is 20.0 k.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Schematic diagram of the methodology. ( A ) Western blot results of TIMP-4 of wild-type and Timp4 defect rats, the protein expression level decrease in a Timp4 -dose dependent manner. ( B ) The measurement of ocular parameters in SD-OCT and the definition of CT, ACD, LT, VCD, and RT by SD-OCT in this study, AL = CT + ACD + LT + VCD + RT. ( C ) The schematic figure of form deprivation; the definition of ocular change. The diffuser was removed after 72 h. ( D ) Measurement of sclera collagen diameter by electron microscopy. The magnification of left image is 1.5 k and the right is 20.0 k.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques: Western Blot, Expressing, Electron Microscopy

Bioinformatic analysis of LoF variants in TIMP4 . ( A ) Conservative analysis of two TIMP4 variants in our study. The red boxes represent the amino acid change of c.528C>A (p.Cys176*) and c.234_235insAA (p.Met80Argfs*26), which are highly conserved among several different vertebrates. ( B ) The distribution and frequency of TIMP4 variants in gnomAD, HGMD, and in-house data.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Bioinformatic analysis of LoF variants in TIMP4 . ( A ) Conservative analysis of two TIMP4 variants in our study. The red boxes represent the amino acid change of c.528C>A (p.Cys176*) and c.234_235insAA (p.Met80Argfs*26), which are highly conserved among several different vertebrates. ( B ) The distribution and frequency of TIMP4 variants in gnomAD, HGMD, and in-house data.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques:

Knock-out of the Timp4 in rats caused abnormal ocular morphogenesis and function. ( A ) Diagram illustrating the structure of knock-out of the Timp4 in rat. ( B ) Sanger sequences confirmed the deletion of the whole Timp4 gene in knock-out rats. ( C ) Interpretation of genotyping: Timp4 +/+ , zero bands in Mix1 and one in Mix2; Timp4 +/− , one band in Mix1 and two in Mix2; Timp4 −/− , one band in both Mix1 and Mix2. ( D ) The TIMP4 expression pattern in human retina and rat retina by immunofluorescence test. The scale bar is indicated by a short white line in the lower right corner of the figure (20 μm). ( E ) Retina thickness (RT) and axial length (AL) of the Timp4 -deficient and wild-type rats decreased from 3W to 52W. The number of animals is provided in the table below. ( F ) ERG results of the Timp4 deficient and wild-type rats at 3 w and 6 w. Compared with wide-type rats, a decrease in b-wave amplitude in 6-week-old Timp4 -deficient rats is shown. Post hoc comparison: 0.01 log scotopic cd.s/m 2 : F = 4.876, η 2 = 0.520, p = 0.037 < 0.05, Timp4 +/+ vs. Timp4 +/− p = 0.041 < 0.05, Timp4 +/+ vs. Timp4 −/− p = 0.637; 3.0 log scotopic cd.s/m 2 : F = 9.256, η 2 = 0.673, p = 0.007 < 0.01, Timp4 +/+ vs. Timp4 +/− p = 0.012, Timp4 +/+ vs. Timp4 −/− p = 0.012; 10.0 log scotopic cd.s/m 2 : F = 5.347, η 2 = 0.543, p = 0.029 < 0.05, Timp4 +/+ vs. Timp4 +/− p = 0.069, Timp4 +/+ vs. Timp4 −/− p = 0.040 < 0.05. The number of animals: Timp4 +/+ = 4, Timp4 +/− = 5, Timp4 −/− = 4. N: number; W: week. A p value of less than 0.05, 0.01, and 0.001 was represented by an asterisk (*), two asterisks (**), three asterisks (***), respectively.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Knock-out of the Timp4 in rats caused abnormal ocular morphogenesis and function. ( A ) Diagram illustrating the structure of knock-out of the Timp4 in rat. ( B ) Sanger sequences confirmed the deletion of the whole Timp4 gene in knock-out rats. ( C ) Interpretation of genotyping: Timp4 +/+ , zero bands in Mix1 and one in Mix2; Timp4 +/− , one band in Mix1 and two in Mix2; Timp4 −/− , one band in both Mix1 and Mix2. ( D ) The TIMP4 expression pattern in human retina and rat retina by immunofluorescence test. The scale bar is indicated by a short white line in the lower right corner of the figure (20 μm). ( E ) Retina thickness (RT) and axial length (AL) of the Timp4 -deficient and wild-type rats decreased from 3W to 52W. The number of animals is provided in the table below. ( F ) ERG results of the Timp4 deficient and wild-type rats at 3 w and 6 w. Compared with wide-type rats, a decrease in b-wave amplitude in 6-week-old Timp4 -deficient rats is shown. Post hoc comparison: 0.01 log scotopic cd.s/m 2 : F = 4.876, η 2 = 0.520, p = 0.037 < 0.05, Timp4 +/+ vs. Timp4 +/− p = 0.041 < 0.05, Timp4 +/+ vs. Timp4 −/− p = 0.637; 3.0 log scotopic cd.s/m 2 : F = 9.256, η 2 = 0.673, p = 0.007 < 0.01, Timp4 +/+ vs. Timp4 +/− p = 0.012, Timp4 +/+ vs. Timp4 −/− p = 0.012; 10.0 log scotopic cd.s/m 2 : F = 5.347, η 2 = 0.543, p = 0.029 < 0.05, Timp4 +/+ vs. Timp4 +/− p = 0.069, Timp4 +/+ vs. Timp4 −/− p = 0.040 < 0.05. The number of animals: Timp4 +/+ = 4, Timp4 +/− = 5, Timp4 −/− = 4. N: number; W: week. A p value of less than 0.05, 0.01, and 0.001 was represented by an asterisk (*), two asterisks (**), three asterisks (***), respectively.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques: Knock-Out, Expressing, Immunofluorescence, Comparison

Axial length, retina thickness, vitreous chamber depth, cornea thickness, anterior chamber depth, and lens thickness of three groups were measured by SD-OCT.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Axial length, retina thickness, vitreous chamber depth, cornea thickness, anterior chamber depth, and lens thickness of three groups were measured by SD-OCT.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques:

The ocular parameters of Timp4 deficient and wild-type rats from 3 w to 52 w measured by OCT. ( A – C ) showed that corneal thickness, anterior chamber distance, and lens thickness increased with age. There were no significant differences between Timp4 deficient and wild-type rats at most time points. ( D ) The result of vitreous chamber distance showed a tendency of Timp4 deficient rats longer than wild-type rats in a Timp4 dose-dependent manner. The number of animals is shown in E. A p value of less than 0.01, and 0.001 was represented by two asterisks (**), and three asterisks (***), respectively.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: The ocular parameters of Timp4 deficient and wild-type rats from 3 w to 52 w measured by OCT. ( A – C ) showed that corneal thickness, anterior chamber distance, and lens thickness increased with age. There were no significant differences between Timp4 deficient and wild-type rats at most time points. ( D ) The result of vitreous chamber distance showed a tendency of Timp4 deficient rats longer than wild-type rats in a Timp4 dose-dependent manner. The number of animals is shown in E. A p value of less than 0.01, and 0.001 was represented by two asterisks (**), and three asterisks (***), respectively.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques:

Ocular changes in the Timp4 defect rats under form deprivation pressure. ( A ) Timeline of ocular biometry and form deprivation. ( B ) Change in RT, VCD, and AL of three-week-old rats before and after FD. The diffusers were removed after 72h. The FD eyes of the Timp4 -deficient rats exhibited more severe retinal thinning, vitreous chamber deepening, and axial elongation than wild-type rats after FD induced. ( C ) The length of PKCα area in FD and non-FD eyes. ( D ) The IF staining of FD and non-FD eye in the mid-peripheral retina of three different genotypes. The red fluorescence represents PKCα and the blue fluorescence represents DAPI. The number of animals: Timp4 +/+ = 6, Timp4 +/− = 5, Timp4 −/− = 4. A p value of less than 0.05, 0.01, and 0.0001 was represented by an asterisk (*), two asterisks (**), and four asterisks (****), respectively. A p value over 0.05 was represented by “ns”.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Ocular changes in the Timp4 defect rats under form deprivation pressure. ( A ) Timeline of ocular biometry and form deprivation. ( B ) Change in RT, VCD, and AL of three-week-old rats before and after FD. The diffusers were removed after 72h. The FD eyes of the Timp4 -deficient rats exhibited more severe retinal thinning, vitreous chamber deepening, and axial elongation than wild-type rats after FD induced. ( C ) The length of PKCα area in FD and non-FD eyes. ( D ) The IF staining of FD and non-FD eye in the mid-peripheral retina of three different genotypes. The red fluorescence represents PKCα and the blue fluorescence represents DAPI. The number of animals: Timp4 +/+ = 6, Timp4 +/− = 5, Timp4 −/− = 4. A p value of less than 0.05, 0.01, and 0.0001 was represented by an asterisk (*), two asterisks (**), and four asterisks (****), respectively. A p value over 0.05 was represented by “ns”.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques: Staining, Fluorescence

Single-channel immunofluorescence of Timp4 -deficient rats and wild-type rats subjected to form deprivation pressure. The treated eye (OD) is the form-deprived (FD) eye, while the control eye (OS) is the non-FD eye. The red fluorescence indicates PKCα, and the blue fluorescence corresponds to DAPI. The number of animals: Timp4 +/+ = 6, Timp4 +/− = 5, Timp4 −/− = 4.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Single-channel immunofluorescence of Timp4 -deficient rats and wild-type rats subjected to form deprivation pressure. The treated eye (OD) is the form-deprived (FD) eye, while the control eye (OS) is the non-FD eye. The red fluorescence indicates PKCα, and the blue fluorescence corresponds to DAPI. The number of animals: Timp4 +/+ = 6, Timp4 +/− = 5, Timp4 −/− = 4.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques: Immunofluorescence, Fluorescence

Morphological observation and concentration detection of collagen in different ocular tissues of 6-week-old rats. ( A ) Collagen content in eye tissues of 6-week-old rats, the collagen contents of the sclera, cornea, and retina in Timp4 -knockdown rats were significantly lower than those in wild-type rats. The number of animals: Timp4 +/+ = 5, Timp4 +/− = 4, Timp4 −/− = 3. ( B ) Diameter of scleral collagen in rats with different genotypes. The collagen fibers of the sclera in Timp4 -deficient rats exhibited varying sizes, unsmooth edges, and larger gaps between adjacent collagen fibers compared with the wild-type. Sclera collagen fiber diameter in Timp4 -gene editing rats was significantly smaller than in wild-type rats. One-way ANOVA, η 2 = 0.1959, p < 0.0001, Timp4 +/+ vs. Timp4 +/− p < 0.0001, Timp4 +/+ vs. Timp4 −/− p < 0.0001. The number of animals: Timp4 +/+ = 4, Timp4 +/− = 4, Timp4 −/− = 4. A p value of less than 0.05 and 0.0001 was represented by an asterisk (*), and four asterisks (****), respectively.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Morphological observation and concentration detection of collagen in different ocular tissues of 6-week-old rats. ( A ) Collagen content in eye tissues of 6-week-old rats, the collagen contents of the sclera, cornea, and retina in Timp4 -knockdown rats were significantly lower than those in wild-type rats. The number of animals: Timp4 +/+ = 5, Timp4 +/− = 4, Timp4 −/− = 3. ( B ) Diameter of scleral collagen in rats with different genotypes. The collagen fibers of the sclera in Timp4 -deficient rats exhibited varying sizes, unsmooth edges, and larger gaps between adjacent collagen fibers compared with the wild-type. Sclera collagen fiber diameter in Timp4 -gene editing rats was significantly smaller than in wild-type rats. One-way ANOVA, η 2 = 0.1959, p < 0.0001, Timp4 +/+ vs. Timp4 +/− p < 0.0001, Timp4 +/+ vs. Timp4 −/− p < 0.0001. The number of animals: Timp4 +/+ = 4, Timp4 +/− = 4, Timp4 −/− = 4. A p value of less than 0.05 and 0.0001 was represented by an asterisk (*), and four asterisks (****), respectively.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques: Concentration Assay

Total collagen concentration and ocular tissue weight of Timp4 -deficient and wild-type rats at 6 weeks old.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Total collagen concentration and ocular tissue weight of Timp4 -deficient and wild-type rats at 6 weeks old.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques: Concentration Assay

Collagen bundle diameter (nm) of the sclera of Timp4 deficient and wild-type rats at 6 weeks old.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Collagen bundle diameter (nm) of the sclera of Timp4 deficient and wild-type rats at 6 weeks old.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques:

Morphology changes in the retina of Timp4 defect rats. ( A ) Schematic diagram of slice observation and retinal layering. ( B ) The location of different cell types and the HE staining of the central, mid-peripheral, and peripheral retina at 3W, 6W, and 9W. Scale bar is indicated by a short black line in the lower right corner of the figure (50 μm). The central, mid-peripheral, and peripheral retinal thickness of the Timp4 -deficient rats compared with wild-type rats at different ages. Detailed data is provided in . The number of animals: 3W, Timp4 +/+ = 3, Timp4 +/− = 6, Timp4 −/− = 4; 6W, Timp4 +/+ = 9, Timp4 +/− = 10, Timp4 −/− = 6; 9W, Timp4 +/+ = 3, Timp4 +/− = 3, Timp4 −/− = 3. A p value of less than 0.05, 0.01, and 0.0001 was represented by an asterisk (*), two asterisks (**), and four asterisks (****), respectively.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Morphology changes in the retina of Timp4 defect rats. ( A ) Schematic diagram of slice observation and retinal layering. ( B ) The location of different cell types and the HE staining of the central, mid-peripheral, and peripheral retina at 3W, 6W, and 9W. Scale bar is indicated by a short black line in the lower right corner of the figure (50 μm). The central, mid-peripheral, and peripheral retinal thickness of the Timp4 -deficient rats compared with wild-type rats at different ages. Detailed data is provided in . The number of animals: 3W, Timp4 +/+ = 3, Timp4 +/− = 6, Timp4 −/− = 4; 6W, Timp4 +/+ = 9, Timp4 +/− = 10, Timp4 −/− = 6; 9W, Timp4 +/+ = 3, Timp4 +/− = 3, Timp4 −/− = 3. A p value of less than 0.05, 0.01, and 0.0001 was represented by an asterisk (*), two asterisks (**), and four asterisks (****), respectively.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques: Staining

Retina thickness (μm) of Timp4 deficient and wild-type rats from HE staining.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Retina thickness (μm) of Timp4 deficient and wild-type rats from HE staining.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques: Staining

The thickness of central retina layers (μm) of Timp4 deficient and wild-type rats from HE staining.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: The thickness of central retina layers (μm) of Timp4 deficient and wild-type rats from HE staining.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques: Staining

IF staining details in the central retina of six-week-old rats under the 40X confocal microscope and bipolar axon length of the central retina. Scale bar is indicated by a short black line in the lower right corner of the figure (20 μm). Red fluorescence: PKC-α (rabbit) & rabbit 568. The figure on the right shows that bipolar cells have shorter axon lengths in the Timp4 -deficient rats than in wild-type rats in the central and mid-peripheral retina (One-way ANOVA, central: Timp4 −/− < Timp4 +/− < Timp4 +/+ , F = 9.032, η 2 = 0.751, p = 0.0155 < 0.05, Timp4 +/+ vs. Timp4 +/− p = 0.0512, Timp4 +/+ vs. Timp4 −/− p = 0.011 < 0.05; mid-peripheral: Timp4 −/− < Timp4 +/− < Timp4 +/+ , F = 5.702, η 2 = 0.650, p = 0.041 < 0.05, Timp4 +/+ vs. Timp4 +/− p = 0.0696, Timp4 +/+ vs. Timp4 −/− p = 0.0343 < 0.05; peripheral: F = 0.06314, p = 0.9394). The number of animals: Timp4 +/+ = 3, Timp4 +/− = 3, Timp4 −/− = 3. A p value of less than 0.05, was represented by an asterisk (*). A p value over 0.05 was represented by “ns”.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: IF staining details in the central retina of six-week-old rats under the 40X confocal microscope and bipolar axon length of the central retina. Scale bar is indicated by a short black line in the lower right corner of the figure (20 μm). Red fluorescence: PKC-α (rabbit) & rabbit 568. The figure on the right shows that bipolar cells have shorter axon lengths in the Timp4 -deficient rats than in wild-type rats in the central and mid-peripheral retina (One-way ANOVA, central: Timp4 −/− < Timp4 +/− < Timp4 +/+ , F = 9.032, η 2 = 0.751, p = 0.0155 < 0.05, Timp4 +/+ vs. Timp4 +/− p = 0.0512, Timp4 +/+ vs. Timp4 −/− p = 0.011 < 0.05; mid-peripheral: Timp4 −/− < Timp4 +/− < Timp4 +/+ , F = 5.702, η 2 = 0.650, p = 0.041 < 0.05, Timp4 +/+ vs. Timp4 +/− p = 0.0696, Timp4 +/+ vs. Timp4 −/− p = 0.0343 < 0.05; peripheral: F = 0.06314, p = 0.9394). The number of animals: Timp4 +/+ = 3, Timp4 +/− = 3, Timp4 −/− = 3. A p value of less than 0.05, was represented by an asterisk (*). A p value over 0.05 was represented by “ns”.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques: Staining, Microscopy, Fluorescence

Timp4 deficient animal model in literatures.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Timp4 deficient animal model in literatures.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques: Animal Model, Expressing, In Vivo

Body weight of experimental rats in this study.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Body weight of experimental rats in this study.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques:

Information of antibody or fluorescent dye used in this study.

Journal: International Journal of Molecular Sciences

Article Title: Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner

doi: 10.3390/ijms242316928

Figure Lengend Snippet: Information of antibody or fluorescent dye used in this study.

Article Snippet: TIMP4 , Tissue inhibitor of matrix metalloproteinase4 , Amino acids residue 30–224 , Rabbit , Invitrogen, USA , PA5-92959 , 1:100.

Techniques: Concentration Assay, Residue

Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Article Title: Canagliflozin Improves Myocardial Perfusion, Fibrosis, and Function in a Swine Model of Chronic Myocardial Ischemia

doi: 10.1161/JAHA.122.028623

Figure Lengend Snippet: Fibrotic Protein Expression

Article Snippet: Ischemic myocardial tissue total protein (40 μg) was fractionated on a 4% to 12% Bis‐Tris gel (ThermoFisher Scientific), transferred to a nitrocellulose or polyvinylidene difluoride membrane (ThermoFisher Scientific, Waltham, MA), and membranes were incubated overnight at 4 °C with 1:1000 dilutions of individual rabbit polyclonal primary antibodies to eNOS, phosphorylated (Ser1177) eNOS, Akt, phosphorylated (Ser473) Akt, ERK1/2 (extracellular signal‐regulated kinase 1/2), phosphorylated ERK1/2, AMPK, phosphorylated (Thr172) AMPK, superoxide dismutase 2, filamin, α‐fodrin, MCP1 (monocyte chemoattractant protein‐1), α‐actinin, β‐actin, desmin, connexin‐43, MMP13 (matrix metalloproteinase 13), mTOR (mammalian target of rapamycin), TIMP2 (tissue inhibitor of metaloproteinase 2), troponin T, troponin I, vimentin, jak2, TGFβ (transforming growth factor beta), SMAD2/3, STAT3 (signal transducer and activator of transcription 3), phosphorylated STAT3 (Cell Signaling, Danvers, MA), and angiostatin (Abcam, Cambridge, UK).

Techniques:

Review

rabbit tissue inhibitor (Biorbyt)

Structured Review

Images

Related Articles

other:

Similar Products

Image Search Results